Table 1 Patient Demographics
| Â | Â | Â | All cases | Upgrading | No upgrading | P value |
|---|---|---|---|---|---|---|
No. of patients | Â | Â | 583 (100%) | 224 (38.4%) | 359 (61.6%) | Â |
Age |  | years (median, IQ) | 66.7 (64.0–71.0) | 67.2 (64.0–71.0) | 66.4 (63.0–71.0) | 0.198 |
PSA |  | ng/ml (median, IQ) | 9.7 (5.5–11.0) | 9.3 (5.5–10.4) | 9.9 (5.5–11.3) | 0.609 |
PV |  | ml (median, IQ) | 32.0 (21.0–38.0) | 32.7 (22.0–39.0) | 31.5 (21.0–37.8) | 0.065 |
PSAD |  | ng/ml2 (median, IQ) | 0.35 (0.18–0.41) | 0.32 (0.18–0.39) | 0.37 (0.18–0.43) | 0.275 |
BMI |  | kg/m2 (median, IQ) | 23.9 (22.0–25.5) | 24.4 (22.4–25.8) | 23.6 (21.9–25.2) | 0.012** |
cT stage | cT1 | no. of patients (% of total) | 461 (79.2%) | 189 (84.4%) | 272 (76.0%) | 0.024* |
cT2a | no. of patients (% of total) | 60 (10.3%) | 23 (10.3%) | 37 (10.3%) | Â | |
cT2b | no. of patients (% of total) | 28 (4.8%) | 9 (4.0%) | 19 (5.3%) | Â | |
cT2c | no. of patients (% of total) | 27 (4.6%) | 3 (1.3%) | 24 (6.7%) | Â | |
cT3–4 | no. of patients (% of total) | 6 (1.0%) | 0 (0%) | 6 (1.7%) |  | |
ISUP gradea | 1 | no. of patients (% of total) | 106 (18.2%) | 89 (39.7%) | 17 (4.7%) | < 0.001* |
2 | no. of patients (% of total) | 233 (40.0%) | 89 (39.7%) | 144 (40.1%) | Â | |
3 | no. of patients (% of total) | 97 (16.6%) | 21 (9.4%) | 76 (21.2%) | Â | |
4 | no. of patients (% of total) | 89 (15.3%) | 25 (11.2%) | 64 (17.8%) | Â | |
5 | no. of patients (% of total) | 58 (9.9%) | Â | 58 (16.2%) | Â | |
Biopsy-prostatectomy interval |  | days (median, IQ) | 133.6 (85–140) | 131.2 (86–139) | 135.2 (85–145) | 0.570 |
%IC |  | %(median, IQ) | 46.0 (21.5–70.0) | 40.8 (16.8–60.0) | 49.3 (30–70.0) | < 0.001* |
Total no. of cores |  | (median, IQ) | 12.0 (9–12) | 11.8 (9–12) | 12.2 (9–13) | 0.441 |
%PC |  | %(median, IQ) | 30.0 (12.5–41.7) | 25.8 (11.1–36.9) | 32.7 (15.4–44.4) | < 0.001* |
Sampling density |  | core/ml (median, IQ) | 0.44 (0.30–0.55) | 0.42 (0.29–0.52) | 0.46 (0.30–0.57) | 0.043* |