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Table 5 Association of the SOAT1 SNPs with the characteristic of HCC patients, dominant model

From: Impacts of the SOAT1 genetic variants and protein expression on HBV-related hepatocellular carcinoma

  Reference genotype Variant genotypes P value P value
rs10753191/
rs3753526
CC/CC
(n = 94)
CT&TT/CG&GG
(n = 127)
  
LDL (mmol/dl) 2.276 ± 0.879 2.353 ± 0.911 0.608 0.606
HDL (mmol/dl) 0.945 ± 0.391 0.984 ± 0.328 0.248 0.237
TC (mmol/dl) 3.803 ± 1.216 3.824 ± 1.190 0.668 0.664
TG (mmol/dl) 1.235 ± 0.952 1.037 ± 0.590 0.384 0.384
Size (cm) 3.987 ± 2.536 4.234 ± 2.892 0.533 0.534
AFP > 20 ng/ml 30 (31.9%) 56 (44.1%) 0.009 § 0.014
HBsAg+ 71 (75.5%) 89 (70.1%) 0.355§ 0.228
Stage(0-B) & 72 (76.6%) 87 (68.5%) 0.0.190§ 0.146
rs13306731 AA
(n = 107)
AG&GG
(n = 114)
  
LDL (mmol/dl) 2.262 ± 0.846 2.376 ± 0.943 0.993 0.993
HDL (mmol/dl) 0.937 ± 0.382 0.995 ± 0.328 0.230 0.219
TC (mmol/dl) 3.749 ± 1.176 3.880 ± 1.221 0.921 0.920
TG (mmol/dl) 1.201 ± 0.913 1.046 ± 0.597 0.246 0.246
size (cm) 3.999 ± 2.514 4.253 ± 2.951 0.518 0.520
AFP > 20 ng/ml 34 (31.8%) 52 (45.6%) 0.003§ 0.010
HBsAg+ 79 (73.8%) 81 (71.1%) 0.498§ 0.352
Stage(0-B)& 80 (74.8%) 79 (69.3%) 0.354§ 0.311
Haplotype CCA
(n = 285)
TGG
(n = 133)
TGA
(n = 24)
TGG P value TGG P value TGA P value TGA P value
LDL (mmol/dl) 2.311 ± 0.911 2.349 ± 0.905 2.259 ± 0.640 0.702 0.774 0.785 0.863
HDL (mmol/dl) 0.955 ± 0.375 1.003 ± 0.318 0.912 ± 0.300 0.206 0.391 0.597 0.592
TC (mmol/dl) 3.829 ± 1.215 3.862 ± 1.221 3.393 ± 0.688 0.802 0.927 0.091 0.100
TG (mmol/dl) 1.178 ± 0.854 1.046 ± 0.587 0.870 ± 0.467 0.115 0.149 0.089 0.067
size (cm) 4.131 ± 2.715 4.228 ± 2.886 3.500 ± 2.077 0.755 0.808 0.311 0.182
AFP > 20 ng/ml 60 (21.1%) 38 (28.6%) 4 (16.7%) 0.042§ 0.065 0.487§ 0.555
HBsAg+ 206 (72.3%) 95 (71.4%) 17 (70.8%) 0.857§ 0.908 0.879§ 0.634
Stage(0-B)& 202 (70.9%) 92 (69.2%) 7 (29.2%) 0.562§ 0.593 0.642§ 0.409
  1. One-way ANOVA
  2. ANOVA adjusted for age and sex
  3. §Logistic regression
  4. Logistic regression adjusted for age and sex
  5. &Stage 0-B versus C-D