Table 5 Association of the SOAT1 SNPs with the characteristic of HCC patients, dominant model
From: Impacts of the SOAT1 genetic variants and protein expression on HBV-related hepatocellular carcinoma
Reference genotype | Variant genotypes | P value† | P value‡ | ||||
|---|---|---|---|---|---|---|---|
rs10753191/ rs3753526 | CC/CC (n = 94) | CT&TT/CG&GG (n = 127) | |||||
LDL (mmol/dl) | 2.276 ± 0.879 | 2.353 ± 0.911 | 0.608 | 0.606 | |||
HDL (mmol/dl) | 0.945 ± 0.391 | 0.984 ± 0.328 | 0.248 | 0.237 | |||
TC (mmol/dl) | 3.803 ± 1.216 | 3.824 ± 1.190 | 0.668 | 0.664 | |||
TG (mmol/dl) | 1.235 ± 0.952 | 1.037 ± 0.590 | 0.384 | 0.384 | |||
Size (cm) | 3.987 ± 2.536 | 4.234 ± 2.892 | 0.533 | 0.534 | |||
AFP > 20 ng/ml | 30 (31.9%) | 56 (44.1%) | 0.009 § | 0.014 ¶ | |||
HBsAg+ | 71 (75.5%) | 89 (70.1%) | 0.355§ | 0.228¶ | |||
Stage(0-B) & | 72 (76.6%) | 87 (68.5%) | 0.0.190§ | 0.146¶ | |||
rs13306731 | AA (n = 107) | AG&GG (n = 114) | |||||
LDL (mmol/dl) | 2.262 ± 0.846 | 2.376 ± 0.943 | 0.993 | 0.993 | |||
HDL (mmol/dl) | 0.937 ± 0.382 | 0.995 ± 0.328 | 0.230 | 0.219 | |||
TC (mmol/dl) | 3.749 ± 1.176 | 3.880 ± 1.221 | 0.921 | 0.920 | |||
TG (mmol/dl) | 1.201 ± 0.913 | 1.046 ± 0.597 | 0.246 | 0.246 | |||
size (cm) | 3.999 ± 2.514 | 4.253 ± 2.951 | 0.518 | 0.520 | |||
AFP > 20 ng/ml | 34 (31.8%) | 52 (45.6%) | 0.003§ | 0.010 ¶ | |||
HBsAg+ | 79 (73.8%) | 81 (71.1%) | 0.498§ | 0.352¶ | |||
Stage(0-B)& | 80 (74.8%) | 79 (69.3%) | 0.354§ | 0.311¶ | |||
Haplotype | CCA (n = 285) | TGG (n = 133) | TGA (n = 24) | TGG P value† | TGG P value‡ | TGA P value‡ | TGA P value‡ |
LDL (mmol/dl) | 2.311 ± 0.911 | 2.349 ± 0.905 | 2.259 ± 0.640 | 0.702 | 0.774 | 0.785 | 0.863 |
HDL (mmol/dl) | 0.955 ± 0.375 | 1.003 ± 0.318 | 0.912 ± 0.300 | 0.206 | 0.391 | 0.597 | 0.592 |
TC (mmol/dl) | 3.829 ± 1.215 | 3.862 ± 1.221 | 3.393 ± 0.688 | 0.802 | 0.927 | 0.091 | 0.100 |
TG (mmol/dl) | 1.178 ± 0.854 | 1.046 ± 0.587 | 0.870 ± 0.467 | 0.115 | 0.149 | 0.089 | 0.067 |
size (cm) | 4.131 ± 2.715 | 4.228 ± 2.886 | 3.500 ± 2.077 | 0.755 | 0.808 | 0.311 | 0.182 |
AFP > 20 ng/ml | 60 (21.1%) | 38 (28.6%) | 4 (16.7%) | 0.042§ | 0.065¶ | 0.487§ | 0.555¶ |
HBsAg+ | 206 (72.3%) | 95 (71.4%) | 17 (70.8%) | 0.857§ | 0.908¶ | 0.879§ | 0.634¶ |
Stage(0-B)& | 202 (70.9%) | 92 (69.2%) | 7 (29.2%) | 0.562§ | 0.593¶ | 0.642§ | 0.409¶ |