Table 3 Associations of SOAT1 SNPs with risk of HBV-HCC
From: Impacts of the SOAT1 genetic variants and protein expression on HBV-related hepatocellular carcinoma
Case (n = 221) | Control (n = 229) | P value | OR(95% CI) | P value† | OR(95% CI)† | P value‡ | OR(95% CI)‡ | |
|---|---|---|---|---|---|---|---|---|
rs10753191 | ||||||||
CC | 94 (42.5%) | 81 (35.4%) | Ref. | / | Ref. | / | Ref. | / |
CT | 97 (43.9%) | 118 (51.5%) | 0.103 | 0.708 (0.475–1.057) | 0.107 | 0.716 (0.477–1.075) | 0.035 | 0.564 (0.331–0.960) |
TT | 30 (13.6%) | 30 (13.1%) | 0.655 | 0.862 (0.479–1.550) | 0.547 | 0.833 (0.460–1.508) | 0.483 | 0.747 (0.331–1.689) |
Dominant | / | / | 0.123 | 0.739 (0.506–1.081) | 0.123 | 0.739 (0.504–1.085) | 0.040 | 0.583 (0.508–2.177) |
Recessive | / | / | 0.891 | 1.042 (0.605–1.794) | 0.965 | 1.012 (0.586–1.749) | 0.893 | 1.051 (0.508–2.177) |
Additive | / | / | 0.237 | 0.840 (0.634–1.122) | 0.277 | 0.858 (0.651–1.131) | 0.156 | 0.764 (0.526–1.108) |
rs13306731 | ||||||||
AA | 107 (48.4%) | 106 (46.3%) | Ref. | / | Ref. | / | Ref. | / |
AG | 95 (43.0%) | 106 (46.3%) | 0.557 | 0.888 (0.604–1.306) | 0.626 | 0.908 (0.614–1.341) | 0.496 | 0.837 (0.502–1.397) |
GG | 19 (8.6%) | 17 (7.4%) | 0.858 | 1.107 (0.546–2.246) | 0.865 | 1.064 (0.519–2.185) | 0.687 | 1.207 (0.483–3.020) |
Dominant | / | / | 0.706 | 0.918 (0.634–1.330) | 0.714 | 0.932 (0.642–1.355) | 0.613 | 0.881 (0.538–1.442) |
Recessive | / | / | 0.729 | 1.173 (0.593–2.320) | 0.706 | 1.141 (0.574–2.268) | 0.558 | 1.299 (0.541–3.122) |
Additive | / | / | 0.750 | 0.963 (0.513–1.563) | 0.898 | 0.981 (0.731–1.317) | 0.892 | 0.974 (0.663–1.430) |