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Table 3 Associations of SOAT1 SNPs with risk of HBV-HCC

From: Impacts of the SOAT1 genetic variants and protein expression on HBV-related hepatocellular carcinoma

  Case
(n = 221)
Control
(n = 229)
P value OR(95% CI) P value OR(95% CI) P value OR(95% CI)
rs10753191
 CC 94 (42.5%) 81 (35.4%) Ref. / Ref. / Ref. /
 CT 97 (43.9%) 118 (51.5%) 0.103 0.708 (0.475–1.057) 0.107 0.716 (0.477–1.075) 0.035 0.564 (0.331–0.960)
 TT 30 (13.6%) 30 (13.1%) 0.655 0.862 (0.479–1.550) 0.547 0.833 (0.460–1.508) 0.483 0.747 (0.331–1.689)
 Dominant / / 0.123 0.739 (0.506–1.081) 0.123 0.739 (0.504–1.085) 0.040 0.583 (0.508–2.177)
 Recessive / / 0.891 1.042 (0.605–1.794) 0.965 1.012 (0.586–1.749) 0.893 1.051 (0.508–2.177)
 Additive / / 0.237 0.840 (0.634–1.122) 0.277 0.858 (0.651–1.131) 0.156 0.764 (0.526–1.108)
rs13306731
 AA 107 (48.4%) 106 (46.3%) Ref. / Ref. / Ref. /
 AG 95 (43.0%) 106 (46.3%) 0.557 0.888 (0.604–1.306) 0.626 0.908 (0.614–1.341) 0.496 0.837 (0.502–1.397)
 GG 19 (8.6%) 17 (7.4%) 0.858 1.107 (0.546–2.246) 0.865 1.064 (0.519–2.185) 0.687 1.207 (0.483–3.020)
 Dominant / / 0.706 0.918 (0.634–1.330) 0.714 0.932 (0.642–1.355) 0.613 0.881 (0.538–1.442)
 Recessive / / 0.729 1.173 (0.593–2.320) 0.706 1.141 (0.574–2.268) 0.558 1.299 (0.541–3.122)
 Additive / / 0.750 0.963 (0.513–1.563) 0.898 0.981 (0.731–1.317) 0.892 0.974 (0.663–1.430)
  1. Adjusted by age, gender
  2. Adjusted by age, gender, HDL, LDL, TC and TG
  3. Dominant model: CC vs. CT + TT for rs10753191; AA vs. AG + GG for rs13306731
  4. Recessive model: TT vs. CC + CT for rs10753191; GG vs. AA+AG for rs13306731
  5. Additive model: CC vs. CT vs. TT for rs10753191; GG vs. AA vs. AG vs. GG for rs13306731