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Table 2 Characteristics of SOAT1 SNPs and haplotypes

From: Impacts of the SOAT1 genetic variants and protein expression on HBV-related hepatocellular carcinoma

SNP rs10753191 rs3753526 rs13306731  
Positiona 179,312,752 179,319,541 179,320,578  
REF C C A  
ALT T G G  
Amino acid change V323V L475L Q526R  
TF bindingb RFX5 No No  
MAFc in CHBd 0.403 0.408 0.306  
MAF in CEUd 0.091 0.040 0.040  
MAF in YRId 0.361 0.116 0  
MAF in the control group 0.394 0.394 0.316  
Hardy-Weinberg Equilibrium P value in the control group 0.197 0.197 0.790  
Haplotype This Study CHB CEU YRI
CCA 0.628 0.592 0.909 0.639
TGG 0.303 0.306 0.040 0.000
TGA 0.069 0.097 0.000 0.116
CGA 0.000 0.005 0.000 0.000
TCA 0.000 0.000 0.051 0.245
  1. aNC_000001.10 (chr1), Feb 2009 GRCh37/hg19)
  2. bTranscriptional factor (TF) binding
  3. cMAF: Minor allele frequency
  4. dGenotype data of CHB, CEU, YRI are all come from 1000Genomes [19]
  5. CHB individuals from unrelated Han Chinese individuals from Beijing, China, CEU residents of Utah with western European ancestry, YRI individuals from Yoruba population of African origin