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Table 3 Common toxicities attributable to study treatment in evaluable patients

From: A Phase 1 dose-escalation study of disulfiram and copper gluconate in patients with advanced solid tumors involving the liver using S-glutathionylation as a biomarker

Event

Grade 1

Grade 2

Grade 3

Total

Elevated AST

3

2

1

6

Fatigue

4

1

1

6

Elevated ALT

3

1

0

4

Nausea

3

1

0

4

Taste changes

2

1

0

3

Vomiting

2

1

0

3

Dizziness

3

0

0

3

Elevated alkaline phosphatase

1

1

1

3

Anorexia

1

0

1

2

Hyperbilirubinemia

1

1

0

2

Thrombocytopenia

1

1

0

2

Hypocalcemia

1

0

0

1

Hypokalemia

1

0

0

1

Hyponatremia

1

0

0

1

Hypoalbuminemia

1

0

0

1

Constipation

1

0

0

1

Flatulence

1

0

0

1

Cough

1

0

0

1

Fever

0

0

1

1

Headache

1

0

0

1

Hypertension

1

0

0

1

Memory impairment

1

0

0

1

Pain (leg)

1

0

0

1