Fig. 4

Actionability of cell cycle and hedgehog pathway genes. The cell cycle pathway is displayed (a). An oncoprint plot is depicted for genetic alterations in cell cycle pathway genes and postulated CDK4/6 actionability (b). The differential distribution of genetic alterations for CCND1 (c) and RB1 (d) between histological subtypes is shown in bar charts. All statistical analyses were performed by the Chi-Square test (Additional file 7). Statistical significance is displayed as *P < 0.05, and **P < 0.01. The hedgehog pathway is shown (e). An oncoprint plot is depicted for genetic alterations in hedgehog pathway genes and their postulated actionability (f). Histological subtypes are abbreviated as HGS = high-grade serous, E = endometrioid and CC = clear cell. In oncoprint plots, * indicates a sample with low (20–30%) tumor purity