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Fig. 1 | BMC Cancer

Fig. 1

From: Genetic alterations and their therapeutic implications in epithelial ovarian cancer

Fig. 1

Alterations of DNA repair-related genes, resulting actionability and tumor mutational burden (TMB). Genetic alterations in DNA repair-related genes and their postulated actionability for PARP inhibition are depicted in oncoprint plots (a). The differential distribution of genetic alterations for BRCA1/2 (b), ARID1A (c) and PTEN (d) between histological subtypes is shown in bar charts. The TMB distribution in the study cohort is depicted (e). Patients of the three histological subtypes were subdivided into those with a TMB > 18 Mut/Mb and < 18 Mut/Mb. All statistical analyses were performed by the Chi-Square test (see Additional file 7). Statistical significance is displayed as *P < 0.05, **P < 0.01, and ***P < 0.001. Genetic alterations in mismatch repair genes are depicted in oncoprint plots, together with the TMB (f). Histological subtypes are abbreviated as HGS = high-grade serous, E = endometrioid and CC = clear cell. In oncoprint plots, * indicates a sample with low (20–30%) tumor purity

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