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Fig. 4 | BMC Cancer

Fig. 4

From: LINC_00355 promotes gastric cancer progression by upregulating PHF19 expression through sponging miR-15a-5p

Fig. 4

LINC_00355 upregulated PHF19 expression through sponging miR-15a-5p in GC cells. a Relative luciferase activity in 293 T cells co-transfected with LINC_00355 reporter plasmid and the candidate miRNA. *P < 0.05 compared with LINC_00355 wt + miR-15a-5p mimic group (b) Relative miR-15a-5p expression levels in HGC-27 and MKN45 cells transfected with si-LINC_00355–1 and − 2. *P < 0.05 compared with si-NC group. c Relative PHF19 protein expression levels in HGC-27 and MKN45 cells transfected with si-LINC_00355–1 and − 2. *P < 0.05 compared with si-NC group. d Relative luciferase activity in 293 T cells co-transfected with PHF19 reporter plasmid and the candidate miRNA. *P < 0.05 compared with PHF19 3′-UTR wt + miR-15a-5p mimic group. e The expression levels of miR-15a-5p in HGC-27 and MKN45 cells transfected with miR-15a-5p mimic, inhibitor, or its corresponding negative control. *P < 0.05 compared with mimic NC group and #P < 0.05 compared with inhibitor NC group. f Relative PHF19 protein levels in HGC-27 and MKN45 cells transfected with miR-15a-5p mimic or inhibitor. *P < 0.05 compared with mimic NC group and #P < 0.05 compared with inhibitor NC group. All values were expressed as mean ± standard deviation. n = 3. GC, gastric cancer; NC, negative control

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