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Table 1 Clinical characteristics

From: The value of complete remission according to positron emission tomography prior to autologous stem cell transplantation in lymphoma: a population-based study showing improved outcome

  N per cent OS LSS PFS
HR (95% CI) HR (95% CI) HR (95% CI)
Sex
 Female 193 37% 1 1 1
 Male 328 63% 1.12 (0.83–1.50) 1.06 (0.72–1.54) 1.01 (0.79–1.30)
Age, years
Median (range) 57 (18–72)
 18–45 126 24% 1 1 1
 46–55 114 22% 2.04 (1.26–3.31) 2.08 (1.09–3.94) 1.70 (1.15–2.51)
 56–65 189 36% 2.99 (1.94–4.61) 2.87 (1.62–5.08) 2.09 (1.47–2.93)
 66–72 92 18% 3.26 (1.97–5.40) 3.43 (1.81–6.52) 2.32 (1.54–3.50)
Lymphoma entity
 Aggressive B cell 121 23% 1 1 1
 Transformed B cell 107 21% 0.80 (0.53–1.20) 0.66 (0.40–1.09) 1.02 (0.72–1.46)
 Indolent B cell 49 9% 0.88 (0.56–1.40) 0.59 (0.32–1.10) 1.15 (0.76–1.74)
 Mantle cell 99 19% 0.50 (0.32–0.78) 0.38 (0.21–0.66) 0.65 (0.45–0.95)
 T cell 85 16% 0.71 (0.47–1.10) 0.51 (0.29–0.90) 0.80 (0.55–1.18)
 Classical Hodgkin 60 12% 0.37 (0.21–0.66) 0.19 (0.08–0.49) 0.54 (0.33–0.87)
Indication for ASCT
 Upfront 183 35% 1 1 1
 Relapsed disease 249 48% 1.85 (1.31–2.62) 1.82 (1.17–2.84) 1.50 (1.13–2.00)
 Refractory disease 88 17% 2.48 (1.64–3.73) 2.58 (1.53–4.36) 1.95 (1.37–2.77)
Calendar period
 1994–2004 112 21% 1 1 1
 2005–2014 239 46% 0.93 (0.67–1.29) 1.15 (0.74–1.77) 0.92 (0.58–1.23)
 2015–2019 170 33% 0.54 (0.34–0.87) 0.74 (0.41–1.33) 0.82 (0.57–1.19)
Number of prior lines of chemotherapy
 1 201 41% 1 1 1
 2 256 52% 1.65 (1.19–2.29) 1.80 (1.18–2.76) 1.44 (1.09–1.89)
 3 or more 37 7% 2.32 (1.33–4.07) 2.70 (1.36–5.39) 1.81 (1.11–2.96)
Conditioning regimen
 BEAM 497 95% 1 1 1
 BEAC 20 4% 1.22 (0.57–2.61) 1.57 (0.69–3.59) 1.59 (0.88–2.84)
 BCNU-Thiotepa 3 1% NA NA NA
 Cy-TBI 1 0% NA NA NA
Rituximab prior to ASCT in B-cell disease
 No 63 17% 1 1 1
 Yes 313 83% 0.61 (0.42–0.87) 0.76 (0.47–1.22) 0.73 (0.53–1.02)
  1. Abbreviations: OS overall survival, LSS lymphoma-specific survival, PFS progression-free survival, ASCT autologous stem-cell transplantation, NA not analyzable