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Table 4 Univariate and multivariate analyses in patients with multiple metastases

From: New insights into patterns of first metastatic sites influencing survival of patients with hormone receptor-positive, HER2-negative breast cancer: a multicenter study of 271 patients

Characteristics

Multiple metastases

Univariate analysis

Multivariate analysis

HRs (95%CI)

p-value

HRs (95%CI)

p-value

Stage at diagnosis

 I + II

1.00

0.076

  

 III

1.695 (0.946–3.030)

   

Adjuvant chemotherapy

 Yes

1.00

0.613

  

 No

1.151 (0.667–1.989)

   

Age at recurrence

 < 50y

1.00

   

 ≥ 50y

0.807 (0.366–1.782)

0.596

  

CEA/CA15–3 serum level

 Normal

1.00

   

 High

1.337 (0.688–2.595)

0.391

  

DFI

 < 2 years

3.229 (1.768–5.895)

< 0.001

3.082 (1.669–5.694)

< 0.001

 ≥ 2 years

1.00

   

Initial therapy for reccurence

 Endocrine therapy

1.00

0.524

  

 Chemotherapy

1.187 (0.700–2.013)

   

Metastatic organ site

 Bone

0.769 (0.455–1.301)

0.328

  

 Lymph node

1.334 (0.790–2.255)

0.281

  

 Lung

0.757 (0.452–1.266)

0.289

  

 Liver

2.915 (1.689–5.025)

< 0.001

3.145 (1.802–5.495)

< 0.001

 Pleura

1.406 (0.781–2.530)

0.256

  

 Brain

2.532 (1.078–5.952)

0.033

3.289 (1.355–7.937)

0.008