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Fig. 1 | BMC Cancer

Fig. 1

From: Transcriptome analysis of potential candidate genes and molecular pathways in colitis-associated colorectal cancer of Mkp-1-deficient mice

Fig. 1

AOM/DSS induced colitis associated colon cancer. (A) Experimental protocols for induction of colitis-associated Adenoma and Adenocarcinoma in WT and Mkp-1−/− mice. BALB/c WT and Mkp-1−/− mice received AOM/DSS for 6 weeks to induce AS, and for 22 weeks to induce CS. (B) Representative images of H&E staining of colonic tumor sections in the WT (a), at the end of AOM/DSS treatment in AS (b, c), and CS (d,e). Normal colons from WT mice without any treatment considered as control (× 200). (C) Tumor size per mouse. SUM represented the sum of tumor sizes of all lengths. Values are mean ± SEM; *P < 0.05, **P < 0.01 vs WT mice. (D) Colon length (the length of tumor colon (cm) / the weight of mice (g) prior to AOM/DSS administration at the beginning of experiment) (n for control = 4, for WT =15, and for Mkp-1−/− = 7), values are mean ± SEM; *P < 0.05, **P < 0.01 vs control mice. AS, adenoma stage; CS, adenocarcinoma stage; WT, wild type

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