Methylation status | Case (%) | Control (%) | Crude OR(95% CI) | P | ORa (95% CI) | P | ORb (95% CI) | P | P-trendc |
---|
ZW | 1 | 151 (44.5) | 79 (23.2) | 1.000 | Â | 1.000 | Â | 1.000 | Â | Â |
2 | 154 (45.4) | 193 (56.6) | 0.417 (0.296–0.589) | < 0.001* | 0.471 (0.285–0.776) | 0.003* | 0.419 (0.286–0.614) | < 0.001* |  |
3 | 34 (10.0) | 69 (20.2) | 0.258 (0.158–0.422) | < 0.001* | 0.407 (0.202–0.821) | 0.012* | 0.274 (0.158–0.474) | < 0.001* | < 0.001* |
- 1: Both ZNF331 and WIF1 were low methylated
- 2: One low and the other high
- 3: Both ZNF331 and WIF1 were high methylated
- CI confidence interval, OR odds ratio, GC gastric cancer
- * Statistically significant
- a Adjusted for age, sex, BMI, monthly income, occupation, family history of GC, H. pylori infection, green vegetables, garlic, beef and mutton, freshwater fish, fried food, refrigerated food, egg, food left overnight, alcohol consumption, water, salted food, dairy products and irregular diet
- b Adjusted for propensity score of all variables
- c The Cochran-Armitage trend test