A composite biomarker of neutrophil-lymphocyte ratio and hemoglobin level correlates with clinical response to PD-1 and PD-L1 inhibitors in advanced non-small cell lung cancers

Table 1 Correlation between NLR and radiographic response

	Response	Non-response	Unknown	Response Rate	Odds Ratio (p value)
A. Baseline NLR
NLR < 5	41	60	45	41%	0.90 (p = 0.87)
NLR ≥ 5	24	39	36	38%	0.90 (p = 0.87)
B. 2–8 weeks NLR
NLR < 5	44	58	31	43%	0.75 (p = 0.41)
NLR ≥ 5	21	37	38	36%	0.75 (p = 0.41)
C. 8–14 weeks NLR
NLR < 5	40	49	18	45%	0.69 (p = 0.31)
NLR ≥ 5	22	39	9	36%	0.69 (p = 0.31)
D. ΔNLR between baseline and 2–8 weeks
ΔNLR< 1	53	64	37	45%	0.47 (p = 0.069)
ΔNLR≥1	12	31	32	28%	0.47 (p = 0.069)
E. ΔNLR between baseline and 8–14 weeks
ΔNLR< 1	50	48	16	51%	0.29 (p = 0.00096)
ΔNLR≥1	12	40	11	23%	0.29 (p = 0.00096)

OR odds ratio (for response in the NLR ≥ 5 group vs. the NLR < 5 group or between the ΔNLR≥1 and ΔNLR< 1)

ISSN: 1471-2407