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Fig. 4 | BMC Cancer

Fig. 4

From: Olaparib-mediated enhancement of 5-fluorouracil cytotoxicity in mismatch repair deficient colorectal cancer cells

Fig. 4

Apoptosis detection. Annexin-V and 7AAD staining was quantified by flow cytometry for HCT116 and HT29 treated with 5-FU and/or Olaparib for 48 h (a) or 72 h (b) (n = 3). Representative dotplots showing cell distribution between compartments in flow cytometry analysis using Annexin-V and 7-AAD staining for HT29 cells (c) or HCT116 cells (d) treated with 5-FU and/or Olaparib for 48 and 72 h. Untreated cells were used as negative control (c). One-way ANOVA and Tukey’s post-hoc tests. *p < 0.05, **p < 0.05, ***p < 0.001 and ****p < 0.0001 above error bars vs. control; #p < 0.05 vs. 5-FU monotherapy in the same concentration

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