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Table 1 Characteristics of Ph + leukemia survivors by diagnosis

From: Patterns of surveillance for late effects of BCR-ABL tyrosine kinase inhibitors in survivors of pediatric Philadelphia chromosome positive leukemias

 

CML (N = 44)

Ph + ALL (N = 22)

N (%)

N (%)

Clinical Characteristics

 Sex

  Male

21 (47.7)

12 (54.5)

  Female

23 (52.3)

10 (45.5)

 Race and ethnicity

  White non-Hispanic

11 (25.0)

7 (31.8)

  Black non-Hispanic

12 (27.3)

3 (13.6)

  Hispanic

5 (11.4)

8 (36.4)

  Asian

14 (31.8)

2 (9.1)

  Other/Not Stated

2 (4.5)

2 (9.1)

 Age at diagnosis, years

13 (3, 20)*

11 (3, 20)*

 Age at censoring, years

19 (6, 35)*

17.5 (6, 26)*

 Time under observation, years

6.3 (1.1, 15.8)*

5.7 (2.1, 11.8)*

Treatment Information

 Tyrosine kinase inhibitor

  Imatinib

35 (79.5)

14 (63.6)

  Dasatinib

26 (59.1)

16 (72.7)

  Nilotinib

7 (15.9)

0 (0.0)

  Ponatinib

2 (4.5)

0 (0.0)

  Bosutinib

1 (2.3)

0 (0.0)

  More than one TKI

21 (47.7)

8 (36.4)

 Duration of TKI treatment, yearsa

6.3 (0.9, 15.6)*

2.8 (0.6, 11.6)*

 Cranial radiation

  Yes

0 (0.0)

6 (27.3)

  No

44 (100.0)

16 (72.7)

 Clinical trial enrollment

  Enrolled

6 (13.6)

9 (40.9)

  Not enrolled

38 (86.4)

13 (59.1)

  1. * Median (minimum, maximum) for continuous variables
  2. aTKI treatment duration for Ph + ALL reflects 1 patient who completed all planned therapy in 0.6 years (hyper-CVAD + TKI) and 6 patients who continued single-agent TKI after upfront therapy