Fig. 2

Cardiac and endocrine surveillance after completion of upfront therapy in patients with Ph + ALL. a Echocardiogram (ECHO) – each circle is an ECHO. b Electrocardiogram (EKG) – each square is an EKG. c Thyroid stimulating hormone (TSH) – each diamond is a TSH. d Dual-energy x-ray absorptiometry (DXA) – each triangle is a DXA. Each line represents a patient. Lines begin at completion of upfront therapy (time 0) and continue until censoring (black X) or relapse (grey X). Unfilled shapes identify surveillance done as a clinical trial requirement. Solid-filled shapes identify surveillance done outside of clinical trial requirements. Bolded timeline indicates single-agent TKI therapy after upfront therapy. For TSH, an asterisk indicates the patient received cranial radiation