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Table 2 Risk factors for axillary non-SLN metastases in breast cancer patients with 1–2 positive sentinel lymph node

From: Development and validation of nomograms for predicting axillary non-SLN metastases in breast cancer patients with 1–2 positive sentinel lymph node macro-metastases: a retrospective analysis of two independent cohorts

 

Model 1

Model 2

Intercept and variable

β

95% OR

P value

β

95% OR

P value

Intercept

−1.298

 

0.003

−1.168

 

0.011

No. of tumor lesions

1.014

2.757 (1.806 to 4.210)

< 0.001

1.034

2.811 (1.812 to 4.361)

< 0.001

Tumor grade

0.664

1.942 (1.246 to 3.027)

0.003

0.655

1.925 (1.217 to 3.045)

0.005

LVI

0.862

2.369 (1.574 to 3.565)

< 0.001

0.866

2.378 (1.558 to 3.630)

< 0.001

No. of positive SLN

1.342

2.740 (1.590 to 4.717)

< 0.001

1.376

2.786 (1.595 to 4.878)

< 0.001

No. of negative SLN

  ≥ 2

reference

  

reference

  

 1

0.979

2.662 (1.393 to 5.087)

0.003

0.750

2.117 (1.085 to 4.130)

0.028

 0

0.729

2.072 (1.099 to 3.907)

0.024

0.568

1.765 (0.919 to 3.390)

0.088

 CA 15–3

NA

NA

NA

1.388

4.006 (2.330 to 6.887)

< 0.001

 CEA

NA

NA

NA

0.898

2.128 (1.323 to 3.425)

0.002

  1. model 1: based on clinicopathological characteristics alone
  2. model 2: based on clinicopathological features and serum tumor markers
  3. Abbreviations: OR odds ratio, LVI lymphovascular invasion, SLN sentinel lymph node, CA carbohydrate antigen, CEA carcinoembryonic antigen