Table 4 Univariate and multivariate Cox regression analyses of the four-gene signature and other prognostic factors for recurrence-free survival in TCGA cohort and TFAHCQMU cohort

 Age (≥60 vs < 60)

1.080

0.770–1.514

0.656

–

–

–

vGender (male vs female)

1.062

0.734–1.536

0.750

–

–

–

 Cirrhosis (positive vs negative)

1.422

0.930–2.176

0.104

–

–

–

 AJCC stage (III-IV vs I-II)

2.493

1.718–3.616

< 0.001***

2.776

1.736–4.440

< 0.001***

 Tumor grade (III-IV vs I-II)

0.981

0.685–1.405

0.917

–

–

–

 Vascular invasion (positive vs negative)

1.730

1.177–2.541

0.005**

1.113

0.741–1.672

0.606

 Signature (high-risk vs low-risk)

3.107

1.783–5.951

< 0.001***

2.553

1.154–5.782

< 0.001***

 Age (≥60 vs < 60)

1.213

0.469–3.134

0.995

–

–

–

 Gender (male vs female)

1.012

0.381–1.821

0.316

–

–

–

 Cirrhosis (positive vs negative)

1.478

0.571–3.826

0.311

–

–

–

 AJCC stage (III-IV vs I-II)

3.954

1.186–9.415

0.016*

2.598

1.546–7.109

0.042*

 Tumor grade (III-IV vs I-II)

1.592

0.615–4.11

0.129

–

–

–

 Vascular invasion (positive vs negative)

2.012

0.785–5.162

0.064

–

–

–

 Signature (high-risk vs low-risk)

5.023

3.422–9.836

< 0.001***

3.289

2.821–8.481

0.002**