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Table 4 In silico validation of TACSTD2 methylation results using TCGA KIRC data

From: DNA methylation of tumor associated calcium signal transducer 2 (TACSTD2) loci shows association with clinically aggressive renal cell cancers

Locus

Position on chromosome 1

1Clinicopathology

2survival data

Metastasis

Tumor stage

Differentiation

 

p

OR

p

OR

p

OR

p

HR

cg21536783

59,041,407

3.10*10−03

65.32

2.40*10−01

2.58

6.11*10−01

1.50

2.97*10−02

1.88

cg00667789

59,042,065

3.91*10−05

44.44

8.56*10−05

14.03

1.34*10−05

18.92

2.97*10−04

2.50

cg00554413

59,042,113

2.14*10−04

104.97

3.34*10−03

14.66

1.32*10− 03

18.75

3.27*10− 02

1.56

cg24851854

59,042,275

5.51*10−07

68.88

3.67*10−08

39.14

3.39*10−08

47.07

4.95*10−06

2.83

cg05065507

59,042,931

1.11*10− 06

65.79

2.03*10−05

31.81

6.40*10−04

19.86

7.70*10− 06

2.66

cg10347335

59,042,971

4.47*10− 07

359.26

2.05*10−05

74.78

8.85*10−04

32.63

1.54*10−03

1.98

cg13443627

59,043,070

8.56*10−07

95.42

2.77*10−06

28.12

1.07*10−05

23.73

4.99*10−04

2.05

cg17210938

59,043,173

2.82*10−05

116.62

1.05*10−05

65.44

1.11*10−03

21.10

1.80*10−05

2.54

cg16080552

59,043,199

5.62*10−06

47.95

3.98*10−05

17.08

1.18*10−04

15.43

4.76*10−07

2.88

cg04863005

59,043,208

5.34*10−06

36.00

1.39*10−05

14.05

2.96*10−04

8.81

1.34*10−05

2.66

cg16699148

59,043,255

2.53*10−04

54.55

3.32*10−03

13.26

1.47*10−02

8.66

6.59*10−03

1.76

cg01821018

59,043,280

3.04*10−04

180.71

1.03*10−02

13.66

1.12*10−02

12.72

7.23*410−02

1.48

cg19813884

59,043,370

8.42*10−06

2179.41

2.3*10−03

80.46

3.10*10−02

23.44

1.61*10−03

1.93

cg05346878

59,043,576

8.10*10−04

16.72

5.51*10−01

1.48

3.58*10−01

1.83

2.82*10−02

1.93

cg27398499

59,043,873

1.13*10−04

27.96

7.97*10−01

1.19

4.06*10−01

1.76

1.19*10−01

1.46

  1. HR Hazard ratio, OR Odds ratio, p p-value, NA not available
  2. 1 univariate logistic regression for methylation comparison of dichotomized tumors for detection of statistical association with distant metastasis (M), high (> = T3) and low stage (< T3), as well as low (< G3) and high grade (> = G3) tumor subsets. Please note that two cpg sites could not be analysed
  3. 2 cox regression analysis for methylation and recurrence free survival