Comparison of breast cancer surrogate subtyping using a closed-system RT-qPCR breast cancer assay and immunohistochemistry on 100 core needle biopsies with matching surgical specimens

Table 1 Clinicopathologic features for the 100 paired breast cancer cases (core biopsy and surgical specimen)

			Core biopsy	Surgical specimen
			n = 100	n = 100
Age at diagnosis Median (range)	61 years (35–93)
Tumor histological subtype		IDC	76	76
		ILC	12	12
		Other	12	12
Tumor histological grade (Nottingham)		1	10	8
		2	71	61
		3	19	31
Tumor size (mm) Median (range)			¨	34.9 (8–159)
Axillary lymph node status		Positive	¨	47
		Negative	¨	51
		N/A^a	¨	2
ER status ≥1% pos		Positive	87	87
ER status ≥1% pos		Negative	13	13
PR status ≥1% pos		Positive	78	81
PR status ≥1% pos		Negative	22	19
Ki-67 Median % staining (range)			15 (4–90)	17.5 (4–95)
HER2 status (HercepTest; SISH in case of score 2+ and 3+)		Positive	18	18
HER2 status (HercepTest; SISH in case of score 2+ and 3+)		Negative	82	82

ISSN: 1471-2407