Table 1 Characteristics of the studies examined in the meta-analysis
Author | Year | Country | Ethnicity | Cancer type | Sample size | Age | Follow-up (month) | Survival analysis | Method | Cut-off value | HR | NOS/REMARK score |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Elhadj [17] | 2019 | Tunisia | Non-Asian | LSCC | 70 | 63 (45–88) | NR | OS, DFS | IHC | 5% | Reported | 7/12 |
Erpolat [18] | 2012 | Turkey | Non-Asian | HNSCC | 58 | 56.7 (35–80) | 56.5 (38.7–112.5) | OS | IHC | 5% | Reported | 7/11 |
Fiedler [19] | 2018 | Germany | Non-Asian | HNSCC | 139 | 60.5 (43.4–83.6) | 17.4 (0–120.9) | OS,DSS | IHC | median value | Reported | 6/14 |
Jin [20] | 2019 | China | Asian | NPC | 164 | 45.0 (24–70) | 49.2 (9–60) | OS,DMFS, LRFS,DFS | IHC, RT-PCR | 0% | Reported | 6/13 |
Li [21] | 2008 | China | Asian | NPC | 280 | 46 (14–86) | NR | OS | IHC | 5% | Reported | 7/11 |
Li [22] | 2011 | China | Asian | LSCC | 86 | 51 (37–84) | NR | OS | IHC | 0% | Reported | 7/12 |
Lin [23] | 2005 | China | Asian | OSCC | 96 | NR | NR | OS | IHC | 25% | Reported | 6/12 |
Muzio [24] | 2005 | Italy | Non-Asian | OSCC | 78 | 66.5 (18–87) | 72 | DSS | IHC | 75% | Reported | 7/12 |
Preuss [25] | 2008 | Australia | Non-Asian | OSCC | 106 | 57 (34–82) | 20.3 (0.33–79.8) | DFS | IHC | 5% | Reported | 7/13 |
Tastekin [26] | 2017 | Turkey | Non-Asian | OSCC | 46 | 59.48 (31–91) | NR | OS | IHC | 13.00% | Reported | 6/11 |
Wang [27] | 2011 | China | Asian | NPC | 1268 | 46 (15–90) | 69 (1–20) | DSS | IHC | median value | Reported | 7/13 |
Xiang [28] | 2006 | China | Asian | NPC | 80 | NR | 60 | OS, DFS | IHC | 25% | Reported | 7/13 |
Yip [29] | 2006 | Canada | Non-Asian | NPC | 198 | NR | 136.8 | OS | IHC | 5% | Reported | 8/15 |
Zhao [30] | 2008 | China | Asian | LSCC | 146 | 54.6 (42–76) | 41.4 (36–72) | DFS | IHC | 5% | Reported | 7/14 |
Dong [31] | 2002 | Japan | Asian | LSCC | 102 | 63.49 (38–89) | NR | OS,DFS | IHC | 5% | Reported | 7/13 |
Kim [32] | 2005 | South Korea | Asian | OSCC | 113 | 58 (18–78) | NR | OS | RT-PCR | 50% | Estimated | 6/12 |
Zhang [33] | 2013 | China | Asian | OSCC | 110 | 58 (37–78) | > 60 | OS | IHC | median value | Estimated | 7/13 |
Farnebo [34] | 2013 | Sweden | Non-Asian | HNSCC | 40 | 68 | 30 | OS | IHC | 0% | Estimated | 6/11 |
Freier [35] | 2007 | Germany | Non-Asian | OSCC | 296 | 60 (16–92) | 34 (0–147) | OS | IHC | 10% | Estimated | 7/13 |
Hansson [36] | 2017 | Sweden | Non-Asian | LSCC | 149 | NR | 67 (9–163) | DFS | IHC | 10% | Estimated | 7/11 |
Munscher [37] | 2019 | Germany | Non-Asian | HNSCC | 452 | NR | 41.3 (1–306) | OS,RFS | IHC | 50% | Estimated | 7/11 |
Pickhard [38] | 2014 | Germany | Non-Asian | HNSCC | 180 | 53 (35–72) | 60–162 | OS | IHC | 10% | Estimated | 6/11 |
Su [39] | 2010 | China | Asian | OSCC | 78 | NR | NR | OS | IHC,RT-PCR | median value | Estimated | 6/11 |
Troiano [40] | 2018 | Italy | Non-Asian | OSCC | 342 | NR | NR | OS | IHC | 60% | Estimated | 7/11 |
Pizem [41] | 2004 | Slovenia | Non-Asian | LSCC | 68 | 59.2 (37–78) | NR | OS | IHC | 50% | Estimated | 6/12 |
Marioni [42] | 2013 | Italy | Non-Asian | LSCC | 33 | NR | 43 | DFS | IHC | 10.00% | Estimated | 6/11 |
Marioni [43] | 2017 | Italy | Non-Asian | LSCC | 75 | 63.6 | 67.3 | DFS | IHC | 6% | Estimated | 7/13 |
Kim [44] | 2010 | South Korea | Asian | OSCC | 38 | 58.5 (40–75) | NR | OS | IHC | 20% | Estimated | 6/11 |