Table 1 Changes in levels of apoptosis related protein in leukemic cell lines
From: Intrinsic and extrinsic apoptosis responses in leukaemia cells following daunorubicin treatment
| Â | MOLT-4 | CCRF-CEM | SUP-B15 | |||
|---|---|---|---|---|---|---|
Apoptotic protein | DNR 4 h | Recovery Medium 12 h | DNR 4 h | Recovery Medium 12 h | DNR 4 h | Recovery Medium 12 h |
Intrinsic Pathway | ||||||
 p53 | ↑ | – | ↑ | – | – | – |
 Bad | ↑ | – | ↑ | – | ↓ | – |
 Bax | ↑ | ↑ | ↑ | – | ↓ | ↓ |
 Bcl-2 | ↓ | – | ↓ | ↓ | ↑ | ↑ |
 Bcl-w | – | – | ↓ | ↓ | ↑ | ↑ |
 cytC | ↑ | ↑ | ↑ | ↑ | ↓ | ↓ |
 SMAC | ↑ | ↑ | ↑ | – | – | – |
Extrinsic Pathway | ||||||
 Fas | ↑ | – | ↑ | – | ↑ | ↑ |
 FasL | ↑ | – | ↓ | ↓ | ↑ | – |
 sTNF-R1 | ↑ | – | ↑ | ↓ | ↓ | ↓ |
 TRAIL-3 | ↑ | – | ↑ | – | ↑ | ↑ |
 TNF-α | ↑ | – | – | ↓ | ↑ | – |
 CD40 | ↑ | – | ↑ | ↓ | ↑ | ↑ |
 Casp-8 | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ |
 Casp-3 | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ |