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Table 1 The chemical structure of the analyzed compounds and their IC50 values. The IC50 are expressed as mean ± SEM obtained from three independent experiments and calculated based on the dose-response curves assessed by the MTT assay (COXIBs and 2,5-DMC), or taken from the literature (TMZ)

From: COXIBs and 2,5-dimethylcelecoxib counteract the hyperactivated Wnt/β-catenin pathway and COX-2/PGE2/EP4 signaling in glioblastoma cells

Compound IC50 [μM] ± SEM Chemical structure
A-172 T98G U-138 MG
Celecoxib 41 ± 7.11 49 ± 1.34 74 ± 0.99
2,5-dimethylcelecoxib
(2,5-DMC)
23 ± 2.25 32 ± 4.86 33 ± 1.72
Etoricoxib > 100 > 100 > 100
Rofecoxib > 100 > 100 > 100
Valdecoxib > 100 > 100 > 100
Temozolomide (TMZ) <  100 > 1000 387.3