Table 1 The chemical structure of the analyzed compounds and their IC50 values. The IC50 are expressed as mean ± SEM obtained from three independent experiments and calculated based on the dose-response curves assessed by the MTT assay (COXIBs and 2,5-DMC), or taken from the literature (TMZ)
Compound | IC50 [μM] ± SEM | Chemical structure | ||
|---|---|---|---|---|
A-172 | T98G | U-138 MG | ||
Celecoxib | 41 ± 7.11 | 49 ± 1.34 | 74 ± 0.99 |
|
2,5-dimethylcelecoxib (2,5-DMC) | 23 ± 2.25 | 32 ± 4.86 | 33 ± 1.72 |
|
Etoricoxib | > 100 | > 100 | > 100 |
|
Rofecoxib | > 100 | > 100 | > 100 |
|
Valdecoxib | > 100 | > 100 | > 100 |
|
Temozolomide (TMZ) | < 100 | > 1000 | 387.3 |
|
