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Fig. 5 | BMC Cancer

Fig. 5

From: COXIBs and 2,5-dimethylcelecoxib counteract the hyperactivated Wnt/β-catenin pathway and COX-2/PGE2/EP4 signaling in glioblastoma cells

Fig. 5

MGMT methylation level in DNA isolated from T98G cells determined using MS-HRM analysis after 48 h of treatment with the analyzed COXIBs, 2,5-DMC, PKF118–310 and 0.5% DMSO (control). The concentration of compounds used in this assay provided at least 70% of cell viability. Normalized melting curves of standardized solutions with a given DNA methylation percentage (indicated with ‘M’) in a background of unmethylated DNA are presented together with the results of the analysis. For clarity, one replicate of each analyzed sample/control is shown

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BMC Cancer

ISSN: 1471-2407

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