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Table 3 Univariate and multivariate analysis for OS of UHFLM, UTCLM and USFLM patients

From: Primary tumor resection improves prognosis of unresectable carcinomas of the transverse colon including flexures with liver metastasis: a preliminary population-based analysis

Variables

UHFLM

UTCLM

USFLM

Univariate analysis

Multivariate analysis

Univariate analysis

Multivariate analysis

Univariate analysis

Multivariate analysis

Age

HR (95%CI)

P value

HR (95%CI)

P value

HR (95%CI)

P value

HR (95%CI)

P value

HR (95%CI)

P value

HR (95%CI)

P value

≤64

Reference

Reference

Reference

Reference

Reference

Reference

65–76

1.397 (1.132–1.726)

0.002

1.278 (1.023–1.595)

0.030

1.245 (1.060–1.462)

0.008

1.273 (1.078–1.503)

0.004

1.193 (0.902–1.579)

0.215

1.162 (0.866–1.559)

0.316

≥77

1.737 (1.393–2.167)

<0.001

1.407 (1.102–1.795)

0.006

1.799 (1.522–2.126)

<0.001

1.482 (1.234–1.779)

<0.001

2.784 (2.110–3.673)

<0.001

1.924 (1.400–2.643)

<0.001

Gender

      

Female

Reference

Reference

Reference

Reference

Reference

Reference

Male

1.004 (0.839–1.201)

0.969

0.987 (0.816–1.193)

0.889

1.014 (0.886–1.161)

0.848

1.049 (0.913–1.205)

0.501

1.103 (0.879–1.385)

0.396

1.122 (0.879–1.432)

0.357

Race

      

White

Reference

Reference

Reference

Reference

Reference

Reference

Black

1.084 (0.859–1.368)

0.499

1.185 (0.927–1.514)

0.176

0.938 (0.792–1.111)

0.458

0.995 (0.832–1.191)

0.959

1.118 (0.844–1.482)

0.437

1.288 (0.945–1.756)

0.110

Other

0.900 (0.656–1.235)

0.514

0.823 (0.582–1.164)

0.271

0.869 (0.674–1.121)

0.280

0.869 (0.671–1.127)

0.291

0.838 (0.565–1.244)

0.381

0.870 (0.572–1.323)

0.514

Year of diagnosis

      

2010–2011

Reference

Reference

Reference

Reference

Reference

Reference

2012–2013

0.822(0.662–1.021)

0.076

0.850 (0.682–1.061)

0.151

0.921 (0.785–1.081)

0.313

0.816 (0.691–0.963)

0.016

0.948 (0.731–1.230)

0.688

0.857 (0.848–1.135)

0.282

2014–2015

0.892(0.716–1.112)

0.311

0.813 (0.648–1.019)

0.073

0.793 (0.667–0.944)

0.009

0.778 (0.650–0.931)

0.006

0.851 (0.634–1.142)

0.282

0.647 (0.474–0.883)

0.006

Marital status

      

Unmarried

Reference

Reference

Reference

Reference

Reference

Reference

Married

0.878 (0.734–1.049)

0.151

1.032 (0.854–1.248)

0.743

0.853 (0.745–0.976)

0.020

0.876 (0.760–1.010)

0.069

0.763 (0.609–0.957)

0.019

0.899 (0.706–1.144)

0.386

MHI (in tens)

      

1926–5768

Reference

Reference

Reference

Reference

Reference

Reference

5769–7177

0.958 (0.780–1.177)

0.685

0.933 (0.753–1.156)

0.526

1.073 (0.717–1.255)

0.381

1.047 (0.890–1.232)

0.579

0.858 (0.657–1.119)

0.258

1.132 (0.854–1.500)

0.390

7178–11,097

0.763 (0.607–0.958)

0.020

0.735 (0.574–1.940)

0.014

0.914 (0.771–1.082)

0.295

0.952 (0.796–1.137)

0.586

0.732 (0.554–0.968)

0.029

0.935 (0.689–1.269)

0.665

Grade

      

I + II

Reference

Reference

Reference

Reference

Reference

Reference

III + IV

1.275 (1.029–1.579)

0.026

1.555 (1.242–1.945)

<0.001

1.526 (1.298–1.794)

<0.001

1.651 (1.392–1.957)

<0.001

1.387 (1.049–1.833)

0.022

1.375 (1.024–1.846)

0.034

Unknown

1.544 (1.236–1.928)

<0.001

1.082 (0.850–1.378)

0.520

1.813 (1.523–2.158)

<0.001

1.373 (1.129–1.671)

0.001

1.687 (1.271–2.239)

<0.001

0.998 (0.702–1.417)

0.990

T stage

      

T1 + T2 + T3

Reference

Reference

Reference

Reference

Reference

Reference

T4

1.413 (1.123–1.779)

0.003

1.511 (1.194–1.913)

0.001

1.266 (1.077–1.487)

0.004

1.113 (0.941–1.317)

0.210

1.220 (0.939–1.586)

0.136

1.444 (1.086–1.920)

0.011

Unknown

1.773 (1.435–2.191)

<0.001

1.213 (0.931–1.581)

0.152

1.689 (1.430–1.994)

<0.001

0.997 (0.805–1.235)

0.977

1.831 (1.373–2.442)

<0.001

1.322 (0.904–1.933)

0.151

N stage

      

N0

Reference

Reference

Reference

Reference

Reference

Reference

N1 + N2

0.990 (0.809–1.210)

0.918

1.489 (1.192–1.861)

<0.001

0.942 (0.810–1.095)

0.437

1.463 (1.231–1.739)

<0.001

0.801 (0.625–1.027)

0.080

1.177 (0.879–1.577)

0.274

Unknown

1.603 (1.218–2.109)

<0.001

1.400 (1.042–1.882)

0.026

1.913 (1.516–2.413)

<0.001

1.418 (1.102–1.835)

0.007

1.399 (0.966–2.026)

0.076

0.876 (0.576–1.332)

0.535

Tumor size

      

 ≤5 cm

Reference

Reference

Reference

Reference

Reference

Reference

>  5 cm

1.199 (0.951–1.511)

0.125

0.968 (0.761–1.232)

0.794

1.247 (1.062–1.464)

0.007

1.075 (0.910–1.270)

0.393

1.435 (1.093–1.884)

0.009

1.170 (0.877–1.561)

0.287

Unknown

1.668 (1.340–2.077)

<0.001

0.928 (0.707–1.219)

0.593

1.832 (1.543–2.176)

<0.001

1.192 (0.970–1.466)

0.095

1.830 (1.366–2.451)

<0.001

0.932 (0.633–1.372)

0.721

CEA

      

Negative

Reference

Reference

Reference

Reference

Reference

Reference

Positive

1.373 (0.984–1.917)

0.062

1.135 (0.807–1.595)

0.467

1.562 (1.237–1.973)

<0.001

1.422 (1.118–1.807)

0.004

1.680 (1.046–2.698)

0.032

1.360 (0.830–2.226)

0.222

Unknown

1.714 (1.200–2.448)

0.003

1.096 (0.757–1.586)

0.627

1.623 (1.263–2.086)

<0.001

1.384 (1.073–1.787)

0.012

1.804 (1.101–2.955)

0.019

1.366 (0.812–2.299)

0.240

PTR

      

No

Reference

Reference

Reference

Reference

Reference

Reference

Yes

0.487 (0.402–0.589)

<0.001

0.341 (0.257–0.453)

<0.001

0.539 (0.470–0.619)

<0.001

0.431 (0.345–0.538)

<0.001

0.479 (0.380–0.603)

<0.001

0.390 (0.267–0.570)

<0.001

Chemotherapy

      

No

Reference

Reference

Reference

Reference

Reference

Reference

Yes

0.390(0.324–0.469)

<0.001

0.343 (0.276–0.425)

<0.001

0.334 (0.290–0.384)

<0.001

0.326 (0.280–0.380)

<0.001

0.285 (0.225–0.361)

<0.001

0.284 (0.214–0.377)

<0.001

  1. Abbreviations: OS overall survival, UHFLM unresectable hepatic flexure cancer liver metastasis, UTCLM unresectable transverse colon cancer liver metastasis, USFLM unresectable splenic flexure cancer liver metastasis, MHI median household income, PTR primary tumor resection
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