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Table 3 Univariate and multivariate analysis for OS of UHFLM, UTCLM and USFLM patients

From: Primary tumor resection improves prognosis of unresectable carcinomas of the transverse colon including flexures with liver metastasis: a preliminary population-based analysis

Variables UHFLM UTCLM USFLM
Univariate analysis Multivariate analysis Univariate analysis Multivariate analysis Univariate analysis Multivariate analysis
Age HR (95%CI) P value HR (95%CI) P value HR (95%CI) P value HR (95%CI) P value HR (95%CI) P value HR (95%CI) P value
≤64 Reference Reference Reference Reference Reference Reference
65–76 1.397 (1.132–1.726) 0.002 1.278 (1.023–1.595) 0.030 1.245 (1.060–1.462) 0.008 1.273 (1.078–1.503) 0.004 1.193 (0.902–1.579) 0.215 1.162 (0.866–1.559) 0.316
≥77 1.737 (1.393–2.167) <0.001 1.407 (1.102–1.795) 0.006 1.799 (1.522–2.126) <0.001 1.482 (1.234–1.779) <0.001 2.784 (2.110–3.673) <0.001 1.924 (1.400–2.643) <0.001
Gender       
Female Reference Reference Reference Reference Reference Reference
Male 1.004 (0.839–1.201) 0.969 0.987 (0.816–1.193) 0.889 1.014 (0.886–1.161) 0.848 1.049 (0.913–1.205) 0.501 1.103 (0.879–1.385) 0.396 1.122 (0.879–1.432) 0.357
Race       
White Reference Reference Reference Reference Reference Reference
Black 1.084 (0.859–1.368) 0.499 1.185 (0.927–1.514) 0.176 0.938 (0.792–1.111) 0.458 0.995 (0.832–1.191) 0.959 1.118 (0.844–1.482) 0.437 1.288 (0.945–1.756) 0.110
Other 0.900 (0.656–1.235) 0.514 0.823 (0.582–1.164) 0.271 0.869 (0.674–1.121) 0.280 0.869 (0.671–1.127) 0.291 0.838 (0.565–1.244) 0.381 0.870 (0.572–1.323) 0.514
Year of diagnosis       
2010–2011 Reference Reference Reference Reference Reference Reference
2012–2013 0.822(0.662–1.021) 0.076 0.850 (0.682–1.061) 0.151 0.921 (0.785–1.081) 0.313 0.816 (0.691–0.963) 0.016 0.948 (0.731–1.230) 0.688 0.857 (0.848–1.135) 0.282
2014–2015 0.892(0.716–1.112) 0.311 0.813 (0.648–1.019) 0.073 0.793 (0.667–0.944) 0.009 0.778 (0.650–0.931) 0.006 0.851 (0.634–1.142) 0.282 0.647 (0.474–0.883) 0.006
Marital status       
Unmarried Reference Reference Reference Reference Reference Reference
Married 0.878 (0.734–1.049) 0.151 1.032 (0.854–1.248) 0.743 0.853 (0.745–0.976) 0.020 0.876 (0.760–1.010) 0.069 0.763 (0.609–0.957) 0.019 0.899 (0.706–1.144) 0.386
MHI (in tens)       
1926–5768 Reference Reference Reference Reference Reference Reference
5769–7177 0.958 (0.780–1.177) 0.685 0.933 (0.753–1.156) 0.526 1.073 (0.717–1.255) 0.381 1.047 (0.890–1.232) 0.579 0.858 (0.657–1.119) 0.258 1.132 (0.854–1.500) 0.390
7178–11,097 0.763 (0.607–0.958) 0.020 0.735 (0.574–1.940) 0.014 0.914 (0.771–1.082) 0.295 0.952 (0.796–1.137) 0.586 0.732 (0.554–0.968) 0.029 0.935 (0.689–1.269) 0.665
Grade       
I + II Reference Reference Reference Reference Reference Reference
III + IV 1.275 (1.029–1.579) 0.026 1.555 (1.242–1.945) <0.001 1.526 (1.298–1.794) <0.001 1.651 (1.392–1.957) <0.001 1.387 (1.049–1.833) 0.022 1.375 (1.024–1.846) 0.034
Unknown 1.544 (1.236–1.928) <0.001 1.082 (0.850–1.378) 0.520 1.813 (1.523–2.158) <0.001 1.373 (1.129–1.671) 0.001 1.687 (1.271–2.239) <0.001 0.998 (0.702–1.417) 0.990
T stage       
T1 + T2 + T3 Reference Reference Reference Reference Reference Reference
T4 1.413 (1.123–1.779) 0.003 1.511 (1.194–1.913) 0.001 1.266 (1.077–1.487) 0.004 1.113 (0.941–1.317) 0.210 1.220 (0.939–1.586) 0.136 1.444 (1.086–1.920) 0.011
Unknown 1.773 (1.435–2.191) <0.001 1.213 (0.931–1.581) 0.152 1.689 (1.430–1.994) <0.001 0.997 (0.805–1.235) 0.977 1.831 (1.373–2.442) <0.001 1.322 (0.904–1.933) 0.151
N stage       
N0 Reference Reference Reference Reference Reference Reference
N1 + N2 0.990 (0.809–1.210) 0.918 1.489 (1.192–1.861) <0.001 0.942 (0.810–1.095) 0.437 1.463 (1.231–1.739) <0.001 0.801 (0.625–1.027) 0.080 1.177 (0.879–1.577) 0.274
Unknown 1.603 (1.218–2.109) <0.001 1.400 (1.042–1.882) 0.026 1.913 (1.516–2.413) <0.001 1.418 (1.102–1.835) 0.007 1.399 (0.966–2.026) 0.076 0.876 (0.576–1.332) 0.535
Tumor size       
 ≤5 cm Reference Reference Reference Reference Reference Reference
>  5 cm 1.199 (0.951–1.511) 0.125 0.968 (0.761–1.232) 0.794 1.247 (1.062–1.464) 0.007 1.075 (0.910–1.270) 0.393 1.435 (1.093–1.884) 0.009 1.170 (0.877–1.561) 0.287
Unknown 1.668 (1.340–2.077) <0.001 0.928 (0.707–1.219) 0.593 1.832 (1.543–2.176) <0.001 1.192 (0.970–1.466) 0.095 1.830 (1.366–2.451) <0.001 0.932 (0.633–1.372) 0.721
CEA       
Negative Reference Reference Reference Reference Reference Reference
Positive 1.373 (0.984–1.917) 0.062 1.135 (0.807–1.595) 0.467 1.562 (1.237–1.973) <0.001 1.422 (1.118–1.807) 0.004 1.680 (1.046–2.698) 0.032 1.360 (0.830–2.226) 0.222
Unknown 1.714 (1.200–2.448) 0.003 1.096 (0.757–1.586) 0.627 1.623 (1.263–2.086) <0.001 1.384 (1.073–1.787) 0.012 1.804 (1.101–2.955) 0.019 1.366 (0.812–2.299) 0.240
PTR       
No Reference Reference Reference Reference Reference Reference
Yes 0.487 (0.402–0.589) <0.001 0.341 (0.257–0.453) <0.001 0.539 (0.470–0.619) <0.001 0.431 (0.345–0.538) <0.001 0.479 (0.380–0.603) <0.001 0.390 (0.267–0.570) <0.001
Chemotherapy       
No Reference Reference Reference Reference Reference Reference
Yes 0.390(0.324–0.469) <0.001 0.343 (0.276–0.425) <0.001 0.334 (0.290–0.384) <0.001 0.326 (0.280–0.380) <0.001 0.285 (0.225–0.361) <0.001 0.284 (0.214–0.377) <0.001
  1. Abbreviations: OS overall survival, UHFLM unresectable hepatic flexure cancer liver metastasis, UTCLM unresectable transverse colon cancer liver metastasis, USFLM unresectable splenic flexure cancer liver metastasis, MHI median household income, PTR primary tumor resection