Table 2 Key adverse events

Immune-related event

21 (21%)

16 (15.1)

2.00 (0.21–3.53)

0.271

Hypothyroidism

11 (11.0)

8 (7.5)

4.00 (0.38–2.71)

0.393

Hyperthyroidism

7 (7.0)

5 (4.7)

1.00 (0.12–3.43)

0.485

Thyroiditis

3 (3.0)

2 (1.9)

2.00 (0.37–4.81)

0.605

Pneumonitis or interstitial lung disease

3 (3.0)

2 (1.9)

2.00 (0.74–4.35)

0.605

Vitiligo

1 (1.0)

1 (0.9)

4.00 (0.28–6.54)

1.000

Colitis

2 (2.0)

2 (1.9)

3.00 (0.43–4.22)

0.953

Fatigue (asthenia)

7 (7.0)

1 (0.9)

3.00 (1.79–3.88)

0.025^a

Musculoskeletal event^b

9 (9.0)

1 (0.9)

5.00 (3.65–6.85)

0.007^a

Fracture^c

1 (1.0)

4 (3.8)

3.00 (0.31–4.76)

0.196

Hypertension^d

1 (1.0)

2 (1.9)

2.00 (0.28–3.41)

1.000

Fall

2 (2.0)

1 (0.9)

2.00 (0.83–3.73)

0.612

Cognitive and memory impairment^e

2 (2.0)

1 (0.9)

2.00 (0.14–3.47)

0.612

Cardiovascular event

2 (1.0)

2 (1.9)

3.00 (0.27–4.19)

0.953