Fig. 6From: Mitochondrial DNA abnormalities provide mechanistic insight and predict reactive oxygen species-stimulating drug efficacyDetailed view of the complex III variation T14798C (F18L). F18 is located at the entrance of the ubiquinone-binding site (Qi site) within the mitochondrial DNA encoded cytochrome b subunit (MT-CYB). MT-CYB is shown in yellow and ubiquinone in green. The wild type F18 is shown in purple sticks and spheres (a & c, respectively) and the mutant L18 is shown in red (b & d). Phenylalanine is a much larger residue than leucine, suggesting that this change is likely to affect the shape and structure of the binding site, the on/off rate of ubiquinone, and consequently alter the activity of complex IIIBack to article page