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Fig. 2 | BMC Cancer

Fig. 2

From: Mitochondrial DNA abnormalities provide mechanistic insight and predict reactive oxygen species-stimulating drug efficacy

Fig. 2

Mitochondrial genetic profiles for PNT-2, Ishikawa, MDA-MB-231, PC-3 and Caco-2. a Relative content of mtDNA in the all cell lines normalised against the house keeping gene (β-actin). The columns represent the relative mtDNAcn of the cell lines. Data are mean ± SEM (N = 3 separate experiments); p values were calculated using one-way ANOVA with Tukey multiple comparison post-hoc analysis; ns, not significant, *p < 0.05 and ***p < 0.001. b Numbers of the total variations observed in the cell lines. c Numbers of variations identified in the D-loop region in the cell lines. d Numbers of non-synonymous variations observed in the whole mtDNA protein coding regions. e Numbers of non-synonymous variations observed in mtDNA coding regions for the complex I and III subunits. f Numbers of non-synonymous variations observed in mtDNA coding regions for the complex IV and V subunits

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