Fig. 1

Intracellular ROS (a) and mitochondrial superoxide (b) levels of the PNT-2, Ishikawa, MDA-MB-231, PC-3 and Caco-2 cell lines are represented by the fluorescence intensity of DCFDA and MitoSOX respectively. Comparison of the CDDP IC50s and the DQA IC50s amongst the 5 cell lines. The columns represent the CDDP IC50s (c) and the DQA IC50s (d) in the all cell lines. Data are mean ± SEM (N = 3 separate experiments); p values were calculated using one-way ANOVA with Tukey multiple comparison post-hoc analysis; ns, not significant, *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001