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Table 2 The selected potential intermediate metabolites of smoking exposure on ESCC by high-dimensional mediation analyses

From: The mediation effect of serum metabolites on the relationship between long-term smoking exposure and esophageal squamous cell carcinoma

Metabolites α β α*β TE %TE FDR
Ever smoking       
Carnitine (9:0) −0.278 −0.552 0.153 1.133 13.53 0.022
Histidine −0.377 −0.745 0.281 1.133 24.80 0.017
Glutamine −0.223 −1.349 0.301 1.133 26.58 0.012
Smoking index       
PG (14:1/7:0) 2.45E-04 0.549 1.35E-04 1.25E-03 10.78 0.037
Carnitine (9:0) −2.60E-04 −0.377 9.82E-05 1.25E-03 7.87 0.037
Histidine −3.45E-04 −1.283 4.43E-04 1.25E-03 35.51 0.008
Glutamine −2.32E-04 −1.590 3.69E-04 1.25E-03 29.54 0.001
Cholic acid −4.57E-03 −0.057 2.62E-04 1.25E-03 21.01 0.037
  1. α: represents changes in the former path of the mediation effect, adjusted for age and gender
  2. β: represents changes in the latter path of the mediation effect, adjusted for age and gender
  3. α*β: represents the mediation effect, adjusted for age and gender
  4. TE, total effect
  5. % TE: the proportion of total effect explained by each mediator, calculated as α*β/TE
  6. FDR, false discovery rate