From: The expression and prognostic value of the epidermal growth factor receptor family in glioma
Characteristic | TCGA (n = 668) | CGGA (n = 326) | ||||
---|---|---|---|---|---|---|
P | HR | 95%CI | P | HR | 95%CI | |
Univariate | ||||||
 Age | < 0.0001 | 1.068 | 1.057–1.078 | < 0.0001 | 1.054 | 1.038–1.070 |
 Gender | 0.144 | 0.826 | 0.639–1.068 | 0.806 | 1.044 | 0.741–1.469 |
 Grade | < 0.0001 | 4.638 | 3.803–5.657 | < 0.0001 | 1.952 | 1.708–2.232 |
 IDH | < 0.0001 | 0.127 | 0.096–0.169 | < 0.0001 | 2.802 | 1.960–4.007 |
 EGFR | < 0.0001 | 1.187 | 1.103–1.278 | 0.808 | 1.013 | 0.914–1.123 |
 ERBB2 | < 0.0001 | 2.177 | 1.884–2.516 | < 0.0001 | 1.961 | 1.613–2.384 |
 ERBB3 | 0.001 | 0.879 | 0.818–0.946 | 0.005 | 0.866 | 0.783–0.958 |
 ERBB4 | < 0.0001 | 0.684 | 0.638–0.734 | < 0.0001 | 0.630 | 0.564–0.703 |
Multivariate | ||||||
 Age | < 0.0001 | 1.033 | 1.021–1.044 | 0.001 | 1.029 | 1.012–1.046 |
 Gender | 0.596 | 0.931 | 0.715–1.212 | 0.482 | 0.882 | 0.620–1.253 |
 Grade | < 0.0001 | 2.218 | 1.727–2.848 | < 0.0001 | 1.752 | 1.485–2.066 |
 IDH | < 0.0001 | 0.341 | 0.235–0.495 | 0.429 | 1.192 | 0.771–1.841 |
 EGFR | 0.459 | 0.978 | 0.921–1.038 | 0.776 | 1.012 | 0.931–1.100 |
 Age | < 0.0001 | 1.032 | 1.020–1.044 | 0.002 | 1.027 | 1.010–1.044 |
 Gender | 0.537 | 0.920 | 0.706–1.199 | 0.531 | 0.894 | 0.629–2.067 |
 Grade | < 0.0001 | 2.185 | 1.700–2.809 | < 0.0001 | 1.751 | 1.483–2.067 |
 IDH | < 0.0001 | 0.375 | 0.253–0.554 | 0.876 | 1.036 | 0.662–1.622 |
 EGFR2 | 0.142 | 1.128 | 0.960–1.326 | < 0.0001 | 1.464 | 1.199–1.786 |
 Age | < 0.0001 | 1.034 | 1.022–1.045 | 0.001 | 1.029 | 1.012–1.045 |
 Gender | 0.646 | 0.940 | 0.722–1.224 | 0.491 | 0.884 | 0.621–1.257 |
 Grade | < 0.0001 | 2.288 | 1.780–2.942 | < 0.0001 | 1.745 | 1.479–2.059 |
 IDH | < 0.0001 | 0.335 | 0.231–0.484 | 0.437 | 1.188 | 0.768–1.835 |
 EGFR3 | 0.032 | 1.077 | 1.006–1.153 | 0.766 | 0.986 | 0.896–1.084 |
 Age | < 0.0001 | 1.033 | 1.021–1.045 | 0.001 | 1.027 | 1.011–1.043 |
 Gender | 0.623 | 0.936 | 0.719–1.218 | 0.678 | 0.927 | 0.650–1.323 |
 Grade | < 0.0001 | 2.282 | 1.755–2.967 | < 0.0001 | 1.575 | 1.322–1.876 |
 IDH | < 0.0001 | 0.333 | 0.227–0.488 | 0.329 | 1.248 | 0.800–1.946 |
 EGFR4 | 0.396 | 1.041 | 0.949–1.141 | < 0.0001 | 0.757 | 0.664–0.864 |