Table 3 GO and KEGG enrichment analysis of the EGFR family and their 20 interactors

BP

GO:0038128

ERBB2 signaling pathway

12

2.95E-21

BP

GO:2000145

regulation of cell motility

10

2.63E-17

BP

GO:0014066

regulation of phosphatidylinositol 3-kinase signaling

10

6.11E-13

BP

GO:0046854

phosphatidylinositol phosphorylation

10

3.83E-12

BP

GO:0048015

phosphatidylinositol-mediated signaling

10

1.18E-11

BP

GO:0018108

peptidyl-tyrosine phosphorylation

10

3.45E-10

BP

GO:0007173

epidermal growth factor receptor signaling pathway

8

1.01E-09

BP

GO:0000165

MAPK cascade

10

4.45E-08

BP

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

8

5.02E-08

BP

GO:0043547

positive regulation of GTPase activity

11

1.83E-06

BP

GO:0042060

wound healing

6

9.38E-05

BP

GO:0008284

positive regulation of cell proliferation

9

1.55E-04

MF

GO:0046934

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

10

5.51E-14

MF

GO:0004713

protein tyrosine kinase activity

11

7.11E-13

MF

GO:0005088

Ras guanyl-nucleotide exchange factor activity

10

1.84E-11

MF

GO:0005154

epidermal growth factor receptor binding

6

5.20E-07

MF

GO:0046875

ephrin receptor binding

5

4.08E-05

MF

GO:0004716

receptor signaling protein tyrosine kinase activity

4

2.80E-04

KEGG

hsa04012

ERBB signaling pathway

18

2.00E-29

KEGG

hsa05214

Glioma

8

1.53E-07

KEGG

hsa05223

Non-small cell lung cancer

7

4.12E-06

KEGG

hsa04722

Neurotrophin signaling pathway

8

1.21E-05

KEGG

hsa05220

Chronic myeloid leukemia

7

1.93E-05

KEGG

hsa04014

Ras signaling pathway

9

4.27E-05

KEGG

hsa05206

MicroRNAs in cancer

9

2.66E-04

KEGG

hsa05205

Proteoglycans in cancer

8

4.15E-04

KEGG

hsa04510

Focal adhesion

8

5.07E-04

KEGG

hsa05215

Prostate cancer

6

0.002482

KEGG

hsa05200

Pathways in cancer

9

0.003013

KEGG

hsa04915

Estrogen signaling pathway

6

0.004453

KEGG

hsa05213

Endometrial cancer

5

0.00888