Table 4 Predictive factors of shorter OS (synchronous) (n = 56)

HR

P-value

HR

95% CI

P-value

Sex, male

1.421

0.139

Age

1.016

0.133

 Location, colon/rectum

0.783

0.303

 Location, right-sided/left-sided

0.818

0.529

 pT stage

1.232

0.344

 Positive lymph node

1.083

0.765

 Tumor distribution: bilobar

1.857

0.009

1.312

0.562–3.138

0.530

 No. of tumors

1.081

0.006

1.063

0.961–1.164

0.223

 No. of tumors (solitary/multiple): multiple

2.930

< 0.001

0.920

0.298–3.230

0.890

 Tumor size ≥5 cm

1.511

0.117

 Serum carcinoembryonic antigen ≥5 ng/mL

1.205

0.514

 Type of hepatectomy: major

1.976

0.005

1.221

0.535–2.765

0.632

 Surgical margin: R1

1.641

0.047

1.718

0.740–3.887

0.202

 KRAS mutational status: KRAS-mut

4.517

< 0.001

4.316

1.973–9.845

< 0.001