Table 3 Predictive factors of shorter OS (metachronous) (n = 45)

HR

P-value

HR

95% CI

P-value

Sex, male

1.060

0.824

Age

1.119

0.854

 Location, colon/rectum

1.035

0.899

 Location, right-sided/left-sided

0.784

0.473

 pT stage

1.204

0.350

 Positive lymph node

1.756

0.042

1.779

1.028–3.223

0.039

 Tumor distribution: bilobar

1.256

0.420

 No. of tumors

1.053

0.127

 No. of tumors (solitary/multiple): multiple

1.489

0.123

 Tumor size ≥5 cm

3.023

< 0.001

3.010

1.734–5.131

< 0.001

 Serum carcinoembryonic antigen ≥5 ng/mL

2.075

0.023

1.701

0.882–3.612

0.117

 Type of hepatectomy: major

1.377

0.328

 Surgical margin: R1

1.898

0.034

2.060

1.122–3.632

0.021

 KRAS mutational status: KRAS-mut

0.608

0.289