Table 2 Predictive factors of shorter OS (n = 101)

HR

P-value

HR

95% CI

P-value

Sex, male

1.209

0.282

Age

1.007

0.344

 Location, colon/rectum

0.888

0.503

 Location, right-sided/left-sided

0.818

0.385

 pT stage

1.274

0.092

 Positive lymph node

1.426

0.062

 Timing of diagnosis: synchronous

1.405

0.050

1.186

0.669–2.144

0.562

 Tumor distribution: bilobar

1.642

0.005

1.106

0.594–2.103

0.752

 No. of tumors

1.072

0.001

 No. of tumors (solitary/multiple): multiple

2.050

< 0.001

1.010

0.523–2.436

0.807

 Tumor size ≥5 cm

2.122

< 0.001

1.092

0.541–2.125

0.801

 Serum carcinoembryonic antigen ≥5 ng/mL

1.586

0.029

1.964

0.991–4.188

0.053

 Type of hepatectomy: major

1.812

0.002

1.415

0.762–2.586

0.268

 Surgical margin: R1

1.805

0.002

2.554

1.385–4.750

0.003

 KRAS mutational status: KRAS-mut

1.860

0.026

2.409

1.361–4.250

0.003