Table 2 Univariate and multivariate analysis of the correlation between clinicopathological parameters and prognostic significance of GBC patients (n = 127)
Variables | Univariate analysis | p value | Multivariate analysis | p value |
|---|---|---|---|---|
HR(95%CI) | HR(95%CI) | |||
Sex (male vs. female) | 1.316 (0.860–2.013) | 0.205 | NA | |
Age (y) (< 68 vs. ≥68) | 1.265 (0.871–1.837) | 0.217 | NA | |
Tumor diameter (cm) (< 2 vs. ≥2) | 1.424 (0.983–2.063) | 0.061 | NA | |
Differentiation (low/undifferentiated vs. high/moderate) | 0.566 (0.387–0.827) | 0.003 | 0.667 (0.428–1.041) | 0.075 |
Depth of invision (T1/TI vs. T3/T4) | 1.683 (1.101–2.572) | 0.016 | 1.359 (0.850–2.172) | 0.200 |
Lymph node metastasis (no vs. yes) | 1.829 (1.249–2.676) | 0.002 | 2.537 (1.123–5.730) | 0.025 |
TNM stages (I/II vs. III/IV) | 1.653 (1.123–2.433) | 0.011 | 0.616 (0.263–1.441) | 0.264 |
Gallstones | 1.026 (0.698–1.508) | 0.896 | NA | |
AFP (< 20 vs. ≥20) | 2.107 (0.853–5.207) | 0.106 | NA | |
CEA (< 5 vs. ≥5) | 1.236 (0.790–1.932) | 0.353 | NA | |
CA199 (< 37 vs. ≥37) | 1.198 (0.816–1.758) | 0.356 | NA | |
INPP4B expression (positive vs. negative) | 0.681 (0.467–0.993) | 0.086 | NA |