Role of Synaptophysin, Chromogranin and CD56 in adenocarcinoma and squamous cell carcinoma of the lung lacking morphological features of neuroendocrine differentiation: a retrospective large-scale study on 1170 tissue samples

Table 6 Multivariate Cox proportional hazard analysis for OS in SqCC

Variable	HR (CI₉₅)	p value
Stage II	1.657 (1.135–2.419)	0.009^a
Stage III	2.889 (1.954–4.274)	< 0.001^a
Stage IV	4.205 (1.298–13.624)	0.017^a
Age (> 59 versus < 59 years)	1.282 (0.900–1.826)	0.168
Gender (female versus male)	0.790 (0.504–1.239)	0.305
Neuroendocrine marker (positivity versus negativity)	0.697 (0.436–1.113)	0.131

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