Role of Synaptophysin, Chromogranin and CD56 in adenocarcinoma and squamous cell carcinoma of the lung lacking morphological features of neuroendocrine differentiation: a retrospective large-scale study on 1170 tissue samples

Table 5 Multivariate Cox proportional hazard analysis for OS in ADC

Variable	HR (CI₉₅)	p value
Stage II	2.76 (1.576–3.581)	< 0.001^a
Stage III	4.649 (3.276–6.597)	< 0.001^a
Stage IV	6.729 (3.726–12.155)	< 0.001^a
Age (> 59 versus < 59 years)	1.036 (0.776–1.384)	0.809
Gender (female versus male)	0.564 (0.420–0.757)	< 0.001
Neuroendocrine marker (positivity versus negativity)	0.876 (0.616–1.247)	0.463

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