Role of Synaptophysin, Chromogranin and CD56 in adenocarcinoma and squamous cell carcinoma of the lung lacking morphological features of neuroendocrine differentiation: a retrospective large-scale study on 1170 tissue samples

Table 4 SqCC patient characteristics and stratification by neuroendocrine marker

	SqCC overall cohort		SqCC neuroendocrine marker positive		SqCC neuroendocrine marker negative		p value
	n	%	n	%	n	%
Patients	543	100	80	100	463
Gender
Male	451	83	67	84	384	83	0.858
Female	92	17	13	16	79	17
Age, median y (range)	65 (38–83)		64 (40–82)		65 (38–83)		0.428
TNM
pT
pT1	106	20	16	20	90	19	0.645
pT2	324	60	48	60	276	60
pT3	93	17	15	19	78	17
pT4	20	4	1	1	19	4
pN
pN0	255	47	35	44	220	48	0.570
pN1	179	33	23	29	156	34
pN2	98	18	20	25	78	17
pN3	1	0	0	0	1	0
pNX	10	2	2	3	8	2
pM
pM1	8	1	2	3	6	1
pMX	535	99	78	98	457	99
Stage
I	185	34	28	35	157	34	0.437
II	208	38	26	33	182	39
III	142	26	24	30	118	25
IV	8	1	2	3	6	1

M metastases, N nodal stage, SqCC squamous cell carcinoma, T tumor size, y year
^apN0 versus pN1/pN2/pN3; pNX not included
^bstage I versus II versus III/IV

ISSN: 1471-2407