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Table 2 IHC staining characteristics of ADC and SqCC tumors

From: Role of Synaptophysin, Chromogranin and CD56 in adenocarcinoma and squamous cell carcinoma of the lung lacking morphological features of neuroendocrine differentiation: a retrospective large-scale study on 1170 tissue samples

 

ADC

SqCC

n

%

n

%

Patients, n

627

100

543

100

General NSCLC markers

 TTF1

  Positivity

548

87

6

1

  Negativity

79

13

537

99

 p40

  Positivity

8

1

511

94

  Negativity

619

99

32

6

Positivity for neuroendocrine marker

 Overalla

110

18

80

15

 Synaptophysin

84

13

20

4

 Chromogranin A

16

3

4

1

 CD56

41

7

3

1

 Synaptophysin / Chromogranin A

12

2

1

0

 Synaptophysin / CD56

19

3

4

1

 Chromogranin A / CD56

10

2

2

0

 Synaptophysin / Chromogranin A / CD56

10

2

0

0

  1. ADC adenocarcinoma, IHC immunohistochemistry, NSCLC non-small cell lung carcinoma, SqCC squamous cell carcinoma
  2. aOverall positivity was defined as positivity for ≥1 neuroendocrine marker