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Table 2 IHC staining characteristics of ADC and SqCC tumors

From: Role of Synaptophysin, Chromogranin and CD56 in adenocarcinoma and squamous cell carcinoma of the lung lacking morphological features of neuroendocrine differentiation: a retrospective large-scale study on 1170 tissue samples

  ADC SqCC
n % n %
Patients, n 627 100 543 100
General NSCLC markers
 TTF1
  Positivity 548 87 6 1
  Negativity 79 13 537 99
 p40
  Positivity 8 1 511 94
  Negativity 619 99 32 6
Positivity for neuroendocrine marker
 Overalla 110 18 80 15
 Synaptophysin 84 13 20 4
 Chromogranin A 16 3 4 1
 CD56 41 7 3 1
 Synaptophysin / Chromogranin A 12 2 1 0
 Synaptophysin / CD56 19 3 4 1
 Chromogranin A / CD56 10 2 2 0
 Synaptophysin / Chromogranin A / CD56 10 2 0 0
  1. ADC adenocarcinoma, IHC immunohistochemistry, NSCLC non-small cell lung carcinoma, SqCC squamous cell carcinoma
  2. aOverall positivity was defined as positivity for ≥1 neuroendocrine marker