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Table 3 Results of the Spearman’s correlation between the clinically and radiologically measured response to the treatment and the difference between the preCHT and postCHT metabolites

From: Molecular response to induction chemotherapy and its correlation with treatment outcome in head and neck cancer patients by means of NMR-based metabolomics

Response to the iCHT

Correlation with the difference between the preCHT- postCHT metabolites

 

All patients

Stratified according to metabolic response

Sex stratified

Grey

Red

Green

M

F

cT-yT

Lip 1.3 ppm (R = -0.31) ↑

NAG (R = 0.33) ↓

Lip 0.9 ppm (R = -0.38) ↑

Lip 1.3 ppm (R = -0.46) ↑

Alanine (R = 0.7) ↓

NAG (R = 0.73) ↓

Lip 0.9 ppm (R = -0.55) ↑

Lip 1.3 ppm (R = -0.57) ↑

Lip 5.3 ppm (R = -0.47) ↑

NAG (R = 0.41) ↓

cN-yN

Primary tumor regression [%]

Alanine (R = 0.77) ↓

LIP 0.9 ppm (R = -0.45) ↑

Lip 1.3 ppm (R = -0.40) ↑

  1. Legend: only statistically significant (p < 0.05, R > 0.3) values are presented. The arrows denote the increase/decrease of the particular metabolites, which is correlated with the tumor downstaging/shrinkage.