Fig. 2

The modified Fig. 1a with the colored mixing cases. The preCHT samples are denoted as the empty triangles: - the nonmixing patients, - the mixing patients starting the treatment with a metabolic profile similar to that of the nonmixing group before the treatment and characterized by a weaker metabolic response than the nonmixing ones, and - the patients starting the treatment with a metabolic profile similar to the Grey patients after the treatment and characterized by a weaker metabolic response than the nonmixing ones. The corresponding postCHT samples are denoted as the full color triangles: , , – the colors have the same meaning as for the preCHT samples. Within the mixing group, except for one patient indicated by the green arrow directed from right to left, the trajectories of the metabolic changes are directed from left (preCHT) to right (postCHT), as expected