Table 3 Summary of forest plot for TRAEs (PP ± B vs. PC + B)
TRAEs | PP ± B n/N (%) | PC + B n/N (%) | Heterogeneity I2 | Heterogeneity P value | RR (95% CI) | P value |
|---|---|---|---|---|---|---|
Drug–related deaths | 9/684 (1.3%) | 13/680 (1.9%) | 0% | 0.845 | 0.84 (0.52,1.37) | 0.491 |
Grade 3/4 TRAEs | ||||||
 Anemia | 97/684 (14.2%) | 23/680 (3.4%) | 2.3% | 0.359 | 1.75 (1.58,1.95) | 0.000 |
 Hypertension | 15/684 (2.2%) | 29/680 (4.3%) | 0% | 0.546 | 0.73 (0.49,1.08) | 0.117 |
 Neutropenia | 161/684 (23.5%) | 267/680 (39.3%) | 1.0% | 0.364 | 0.67 (0.59,0.77) | 0.000 |
 Thrombocytopenia | 144/684 (21.1%) | 42/680 (6.2%) | 25.3% | 0.262 | 1.70 (1.47,1.96) | 0.000 |
 Sensory neuropathy | 1/684 (0.1%) | 26/680 (3.8%) | 0% | 0.384 | 0.21 (0.06,0.76) | 0.017 |
 Febrile neutropenia | 6/684 (0.9%) | 22/680 (3.2%) | 0% | 0.875 | 0.47 (0.25,0.90) | 0.023 |