Fig. 4

RPF density (A-site density) on different alleles of synonymous sites. a For optimal synonymous sites, the A-site densities on ancestral alleles in normal sample, ancestral alleles in tumor sample, and derived alleles in tumor sample were plotted. KS tests were used to calculate the p-values. b For optimal synonymous sites, the A-site densities on two alleles in tumor sample were compared. Paired t-test was used to calculate the p-value. c For non-optimal synonymous sites, the A-site densities on ancestral alleles in normal sample, ancestral alleles in tumor sample, and derived alleles in tumor sample were plotted. KS tests were used to calculate the p-values. b For non-optimal synonymous sites, the A-site densities on two alleles in tumor sample were compared. Paired t-test was used to calculate the p-value