Table 2 Univariable and multivariable Cox proportional regression analysis of factors associated with OS in BMs patients

1.02 (1.02–1.03)

0.001

1.01 (1.01–1.01)

0.001

Facility Type

Academic

0.81 (0.80–0.82)

0.001

0.85 (0.84–0.87)

0.001

Non-academic

Ref

Sex

Male

Ref

Ref

Female

0.82 (0.81–0.83)

0.001

0.86 (0.85–0.88)

0.001

Race

White

Ref

Ref

Black

0.95 (0.93–0.97)

0.001

0.94 (0.91–0.96)

0.001

non-white non-black

0.69 (0.67–0.72)

0.001

0.73 (0.70–0.76)

0.001

Education

> = 13% NHD

1.07 (1.05–1.08)

0.001

…

< 13% NHD

Ref

Income

> = $35,000

Ref

Ref

<$35,000

1.12 (1.10–1.13)

0.001

1.06 (1.04–1.07)

0.001

Place of Living

Urban

Ref

Ref

Rural

1.08 (1.04–1.134)

0.004

….

Insurance Status

Insured

Ref

Not insured

1.04 (1.01–1.07)

0.02

1.11 (1.08–1.15)

0.001

Charlson/Deyo Score

0

Ref

Ref

1

1.25 (1.24–1.28)

0.001

1.14 (1.13–1.16)

0.001

> = 2

1.50 (1.47–1.53)

0.001

1.23 (1.20–1.26)

0.001

Primary Site Surgery

Yes

Ref

0.001

Ref

0.001

No

2.24 (2.14–2.34)

2.13 (2.03–2.23)

Chemotherapy

Yes

Ref

Ref

No

2.37 (2.34–2.40)

0.001

2.19 (2.15–2.22)

0.001

Radiation Therapy

Yes

Reference

Reference

No

1.62 (1.59–1.64)

0.001

1.25 (1.22–1.27)

0.001

Immunotherapy

Yes

Ref

Ref

No

1.91 (1.83–1.99)

0.001

1.45 (1.39–1.52)

0.001

Year of Diagnosis

2010–2013

1.09 (1.07–1.10)

0.001

1.06 (1.05–1.08)

0.001

2014–2015

Ref

Ref

Primary Cancer Type

Breast cancer

0.72 (0.68–0.76)

0.001

0.74 (0.70–0.78)

0.001

NSCLC

1.09 (1.04–1.13)

0.001

1.06 (1.02–1.11)

0.009

SCLC

1.20 (1.15–1.25)

0.001

1.24 (1.19–1.30)

0.001

Other lung

2.26 (2.16–2.38)

0.001

1.39 (1.32–1.46)

0.001

Melanoma

1.01 (0.95–1.07)

0.77

0.78 (0.74–0.83)

0.001

Colorectal cancer

1.20 (1.11–1.29)

0.001

1.26 (1.166–1.36)

0.001

Renal cell

Ref

Ref