Fig. 3

Prevalence along the germline RET mutations/variants in our series. Fifty-five different variants of RET were found in 276 patients with confirmed or suspected MEN2. Of them, 38 were pathogenic including 19 (18 point and 1 del/ins) single and 19 compound mutations in 245 patients. The remaining 17 variants in 31 patients, 3 were considered as pathogenic variants in 12 patients, other 12 variants of unknown significance (VUS; 10 of uncertain significance and 2 of likely benign) or 2 as benign in 19 patients