Fig. 2

Age-dependent penetrancies of MEN2A-related MTC/PHEO carrying RET single pathogenic mutations. a Age at the diagnosis of presence or absence of MTC or PHEO for 194 MEN2A patients, for 98 patients with mutations in exon 11, and for 71 patients with mutations in exon 10, respectively. Student’s t-test was used to compare mean of age (mean ± SD). b Of 169 patients, Kaplan-Meier estimates of MTC (shown in b-1) or PHEO (shown in b-2)-specific presence in 98 patients carrying mutations in exon 11 versus 71 patients carrying mutations in exon 10. The log-rank test was used to compare curves, P = 0.041 or P = 0.000, respectively