Fig. 7
From: PTEN loss correlates with T cell exclusion across human cancers
Predictive value of PTEN expression in patients receiving immunotherapy. a Bar plot and heatmap demonstrated the mRNA expression (log transferred) level of PTEN and immune related genes (CD4, CD8A, VEGFA) respectively for patients receiving anti-CTLA4 blockade or anti-PD-1 blockade in Chen et al. cohort, with the samples ranked in the ascending order according to PTEN expression. Response to immunotherapy (R: response; NR: not response) was denoted by the color of the bar. Patients with higher PTEN expression demonstrated higher expression of T infiltration markers (CD4, CD8) and better response to CTLA-4 blockade or PD-1 blockade in Chen et al. cohort. b Bar plot and heatmap demonstrated the mRNA expression (log transferred) level of PTEN and immune related genes (CD4, CD8A, VEGFA) respectively for patients receiving anti-PD-1 treatment in Riaz et al. cohort, with the samples ranked in the ascending order according to PTEN expression. Response to immunotherapy (CR: complete response; PR: partial response; SD: stable disease; PD: progressed diseased) was denoted by the color of the bar. Patients with higher PTEN expression demonstrated higher expression of T infiltration markers (CD4, CD8) and better response PD-1 blockade in Riaz et al. cohort. c Kaplan-Meier plots of overall survival difference between patients with low PTEN expression (the bottom fifth, n = 10) and high PTEN expression (the top four fifths, n = 39) in Riaz et al. cohort. Patients with higher PTEN expression demonstrated improved overall survival after anti-PD-1 immunotherapy in Riaz et al. cohort