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Fig. 4 | BMC Cancer

Fig. 4

From: PTEN loss correlates with T cell exclusion across human cancers

Fig. 4

Difference of T cells infiltration or immunosuppressive markers between tumors with PTEN loss and tumors with Intact PTEN. T cells (CD8+ T cells, Th1 cells, Th2 cells) infiltration level and mRNA Expression of Immunosuppressive markers (PD-L1, encoded by CD274; PD-1, encoded by PDCD1; VEGF, encoded by VEGFA) between tumor with PTEN loss or Intact PTEN. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001; ns, not significant. Tumors with PTEN loss demonstrated significant lower infiltrating level of CD8 T cell and type 1 T helper cells (Th1 cells) and expression level, but increased infiltration of type 2 T helper cells (Th2 cells) and expression of VEGFA in multiple cancer types. No general pattern was observed for the correlation of PTEN status with expression level of PDCD1 and CD274 among different cancer types. Abbreviations: full terms of cancer abbreviation were shown in Fig. 2

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