Skip to main content
Fig. 6 | BMC Cancer

Fig. 6

From: Humanized anti-DEspR IgG4S228P antibody increases overall survival in a pancreatic cancer stem cell-xenograft peritoneal carcinomatosis ratnu/nu model

Fig. 6

DEspR is expressed in human PDAC primary and metastatic tumors. a Representative immunofluorescence images of cryo-sections of normal human pancreas and human PDAC Stage-II-B tumors probed with AF568-labeled 7c5[epitope-1] murine-mAb (red) and DAPI+ nuclei (blue). Bar = 20 μm. b Representative immunofluorescence images of paraffin-embedded, antigen-retrieved sections of [Left] human normal pancreas and [Right] human PDAC primary tumors at different stages (I-IV), and metastatic (met.) tumors probed with AF568-labeled hu-6g8[epitope2] (red); DAPI nuclear-DNA stain (blue), with DIC overlay. Bar = 20 μm. c Quantitation of human tumors with > 50% vs < 50% tumor proportion score (TPS) for DEspR+ expression detected by AF568-hu-6g8, n = 133 PDAC-patient tumor-cores on tumor array. d Quantitation of DEspR expression of invading PDAC TCs in primary tumors with invasive tumor cells in stroma; n = 79 PDAC-patient tumor-cores

Back to article page